Nimbolide I30002 GSK591 potently inhibits the PRMT5/MEP50

GSK591 potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50 = 11 nM

Yamaguchi Y

A-966492 is a potent PARP inhibitor

a potent inhibitor of Wnt/β-cateninsignaling and colorectal cancer growth

and is efficacious in collagenase and surgery induced OA models in mice

Nimbolide I30002 GSK591 potently inhibits the PRMT5/MEP50Nimbolide is a natural inhibitor of pancreatic cancer growth and metastasis through ROS mediated apoptosis. It inhibits epithelial to mesenchymal transition. Product information CAS Number: 25990 37 8 Molecular Weight: 466. 52 Formula: C27H30O7 Chemical Name: 8(R) (3 Furanyl) 2aR, 5aR, 6S, 6aR, 8R, 9, 9aR, 10aS, 10bR, 10cR decahydro 2a, 5a, 6a, 7 tetramethyl 2, 5 dioxo 2H, 5H cyclopenta[d']naphtho[1, 8 bc: 2, 3 b']difuran 6 acetic acid, methyl ester