b-AP15 (NSC687852) - Deubiquitinases Inhibitor. CAS# 1009817-63-3 0023 Using photo-affinity labeling
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b-AP15 (NSC687852) - Deubiquitinases Inhibitor. CAS# 1009817-63-3 0023 Using photo-affinity labelingb AP15 (NSC686852), CAS No. 1009817 63 3, is a potent and selective deubiquitinases inhibitor for 19S proteasomes activity of Ub AMC cleavage with IC50 of 2. 1 M. It inhibits the activity of two 19S regulatory particle associated deubiquitinases, UCHL5 and USP14, resulting in accumulation of polyubiquitin. It has minimal inhibition of UCHL 1, UCHL 3, USP2, USP7, USP, BAP1 and proteasome activity. b AP15 induces apoptosis by cathepsin D dependent
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