Tamibarotene - CAS# 94497-51-5 oxifen citrate 5-c]pyridine-6-carboxylic acid

5-c]pyridine-6-carboxylic acid

JW74 induces reduced cell growth in all three tested cell lines

inhibition of TPH1 occurred in 10(-8) -10(-7) mol L(-1) range

InChiKey: ACGUYXCXAPNIKK-UHFFFAOYSA-N

functioning as an inhibitor of matrix metalloproteinases

Tamibarotene - CAS# 94497-51-5 oxifen citrate 5-c]pyridine-6-carboxylic acidTamibarotene, also known as SY 1425, is an orally active, synthetic retinoid, developed to overcome all trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. As a specific retinoic acid receptor (RAR) alpha beta agonist, tamibarotene is approximately ten times more potent than ATRA in inducing cell differentiation and apoptosis in HL 60 (human promyelocytic leukemia) cell lines in vitro. Due to a lower affinity for cellular