Crizotinib Hydrochloride - CAS# 1415560-69-8 Catalog No.:M10974-2 Formula: C25H28N6O2

Formula: C25H28N6O2

InChi: InChI=1S/C16H15N3O/c1-20-15-9-7-13(8-10-15)17-16-11-12-19(18-16)14-5-3-2-4-6-14/h2-12H

45 Suppl 4

In a concentration of 128 mcg/mL Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain Sofiin) by accumulation in the SKEV cell culture

HI-TOPK-032 strongly suppressed TOPK kinase activity but had little effect on extracellular signal–regulated kinase 1 (ERK1)

Crizotinib Hydrochloride - CAS# 1415560-69-8 Catalog No.:M10974-2 Formula: C25H28N6O2Crizotinib (PF 02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c Met and nucleophosmin (NPM) anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0. 025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. Product information CAS Number: 1415560 69 8