GW-627368X - CAS# 439288-66-1 60249 Characterisation of a Tip60 specific

Characterisation of a Tip60 specific inhibitor

Molecular Weight: 416

Bay 11-7085 induces apoptosis of ECSCs by suppressing antiapoptotic proteins

Afuresertib significantly increases caspase-3 and caspase-7 activities and apoptotic cell number among ACC-MESO-4 and MSTO-211H cells

PubMed PMID: 19740074

GW-627368X - CAS# 439288-66-1 60249 Characterisation of a Tip60 specificGW 627368X, CAS No. 439288 66 1, is a novel, potent and selective competitive antagonist of prostanoid EP4 receptors with additional human TP receptor affinity. Oral administration of GW627368X showed significant tumor regression characterized by tumor reduction and induction of apoptosis. Reduction in prostaglandin E2 synthesis also led to reduced level of VEGF in plasma. GW627368X will be a valuable tool to explore the role of the prostanoid EP4