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VLX1570 - CAS# 1431280-51-1 size:10mg solid InChi: InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24

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VLX1570 - CAS# 1431280-51-1 size:10mg solid InChi: InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24VLX1570, CAS No. 1431280 51 1, is an inhibitor of the 19S proteasome specific deubiquitylating enzymes (DUBs) USP14 and UCHL5, with apoptosis inducing and antineoplastic activities. Upon administration, VLX1570 specifically binds to both USP14 and UCHL5, thereby blocking their deubiquitylating activity. This blocks the ubiquitin proteasome degradation pathway, prevents the degradation of defective proteins, and leads to an accumulation of poly

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InChi: InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24

and in a murine ocular herpes model

Virshup IH

is effective in shrinking tumors in both C/L858R and C/L+T mice

6 mg/kg/day

VLX1570 - CAS# 1431280-51-1 size:10mg solid InChi: InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24VLX1570, CAS No. 1431280 51 1, is an inhibitor of the 19S proteasome specific deubiquitylating enzymes (DUBs) USP14 and UCHL5, with apoptosis inducing and antineoplastic activities. Upon administration, VLX1570 specifically binds to both USP14 and UCHL5, thereby blocking their deubiquitylating activity. This blocks the ubiquitin proteasome degradation pathway, prevents the degradation of defective proteins, and leads to an accumulation of poly

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