AUY-922 - CAS# 747412-49-3 Catalog No.:M6487-10 a BET bromodomain inhibitor now

a BET bromodomain inhibitor now in clinical development

PubMed Central PMCID: PMC3955649

69(5):1916-23

is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM

NVP-TAE684 markedly reduces cell survival in both sensitive H3122 and H3122 CR cells

AUY-922 - CAS# 747412-49-3 Catalog No.:M6487-10 a BET bromodomain inhibitor nowAUY 922, also known as Luminespib, NVP AUY922, VER52296, CAS No. 747412 49 3, is a derivative of 4, 5 diarylisoxazole and a third generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90 inhibitor AUY 922 has been shown to bind with high affinity to and inhibit Hsp90, resulting in the proteasomal degradation of oncogenic client proteins; the inhibition of cell proliferation; and the elevation of heat shock