ML-329 - CAS# 19992-50-8 072 Bolhassani M

Bolhassani M

Potent antitumor activity of HSP90 inhibitor AUY922 in adrenocortical carcinoma

Aticaprant (CERC-501) shows no appreciable affinity for several non-opioid cell surface G-protein-coupled receptor targets

CAS Number: 1638250-96-0

and -9-mediated cascades are involved in this mechanism

ML-329 - CAS# 19992-50-8 072 Bolhassani MML 329, CAS No. 19992 50 8, is an inhibitor of the microphthalmia associated transcription factor (MITF) pathway with an IC50 value of 1. 2 M for promoter activity of the MITF target gene TRPM 1. ML 329 showed specific activity against the MITF dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML 329 reduced the expression of multiple MITF target genes, including pigment related genes and the cell cycle regulator CDK2.