Ro 31-8220 Size:Solid 10 mg UK5099 significantly inhibits the glucose-stimulated

UK5099 significantly inhibits the glucose-stimulated rise in oxygen consumption in a dose-dependent manner and at 150 μM reduced oxygen consumption below basal levels

CAS Number: 1314890-29-3

InChi: InChI=1S/C27H26N4O4S

2-dimethyl-2H-thiochromen-6-yl]ethynyl}benzoic acid

Chemical Name: 2-[(5-nitro-1

Ro 31-8220 Size:Solid 10 mg UK5099 significantly inhibits the glucose-stimulatedRo 31 8220 is a PKC inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC activators phorbol myristate acetate (PMA, IC50 = 1. 35 x 10( 6) M) or diacylglycerols (OAG, diC8) by 95%. Ro 31 8220 showed the apoptotic effect on HL 60 cells, which was mediated by a well characterized transduction process of apoptotic signals: i. e., mitochondrial cytochrome c efflux and the activation of caspase 3 in the cytosol. Moreover,