Vinflunine Size:Solid 2 mg 1'-biphenyl]-3-carbonitrile

1'-biphenyl]-3-carbonitrile

Combination of menadione and DMXAA leads to an increase in the antiproliferative activity of DLD-1 cells

A phase I study of KPT-330in combination with high-dose cytarabine and mitoxantrone for remission induction in patients with acute myeloid leukemia

CAS Number: 2719-05-3

Molecular Weight: 582

Vinflunine Size:Solid 2 mg 1'-biphenyl]-3-carbonitrileVinflunine is a bi fluorinated derivative of the semi synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis.