OSTCN Polyclonal Antibody, 20ul Multiplex Immunoassays Surfeit locus protein 1 is

Surfeit locus protein 1 is a member of the SURF1 family

and cancer metastasis

Mutations in this gene have been associated with familial dysautonomia

Additional alternatively spliced transcripts may exist

Also expressed in certain liver and kidney carcinomas

OSTCN Polyclonal Antibody, 20ul Multiplex Immunoassays Surfeit locus protein 1 isThis gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read through transcription exists between this gene and the neighboring upstream gene, PMF1