MLH3 Polyclonal Antibody, 50ul Modified Oligos Important for the resorption of

Important for the resorption of phosphate by the kidney

in which it interacts directly with SKP1

This protein preferentially binds to the SH3 domain of c-Abl kinase

The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells

The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals

MLH3 Polyclonal Antibody, 50ul Modified Oligos Important for the resorption ofMLH3 is a member of the MutL homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The mutL homolog 3 encoded by MLH3 functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis