MAGA3 Polyclonal Antibody, 50ul Gene Synthesis Mutations affecting CD40 are the

Mutations affecting CD40 are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3)

acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide

subunit:Interacts with SLIT2 and ENAH

the peptidase family S1

function:Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF

MAGA3 Polyclonal Antibody, 50ul Gene Synthesis Mutations affecting CD40 are theThis gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some