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Alterations in this gene may also be associated with Crohn's disease

IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains| but this gene encodes proteins with only a single BIR domain

nuclear and mitochondrial splicing

Alternativley spliced transcript variants encoding different isoforms have been identified in this gene

VCAM-1 Rabbit Polyclonal Antibody, 20ul Metabolic enzymes tool compounds Take on new challenges withThis gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine activated endothelium. This type I membrane protein mediates leukocyte endothelial cell adhesion and signal transduction and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.