Desmin Monoclonal Antibody(1B12), 20ul Immune Repertoire Sequencing Inhibits SIRT1 deacetylase activity leading

Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis

s an activator of NLRP3 inflammasome assembly

4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin

The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine

The peptide binding cleft accommodates peptides of 10-30 residues

Desmin Monoclonal Antibody(1B12), 20ul Immune Repertoire Sequencing Inhibits SIRT1 deacetylase activity leadingThis gene encodes a muscle specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.