DEN1A Rabbit Polyclonal Antibody, 100ul Antibodies increased susceptibility to rheumatoid arthritis

increased susceptibility to rheumatoid arthritis

A pseudogene of this gene is found on chromosome 16

The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase| which may mediate insulin signals to the actin cytoskeleton

Alternatively spliced transcript variants encoding multiple isoforms have been observed for CASP7

and may also regulate the cystic fibrosis transmembrane regulator(CFTR) ion channel

DEN1A Rabbit Polyclonal Antibody, 100ul Antibodies increased susceptibility to rheumatoid arthritisClathrin (see MIM 118955) mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family such as DENND1A function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein 2 (AP2; see MIM 601024). Thus connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson 2010