Ku-70 Polyclonal Antibody, 50ul[BT-AP04893] Serum & Sample Tubes disease:Defects in CDKN2A are a

disease:Defects in CDKN2A are a cause of Li-Fraumeni syndrome (LFS)

The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules

lymph node and thymus

It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle

The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus

Ku-70 Polyclonal Antibody, 50ul[BT-AP04893] Serum & Sample Tubes disease:Defects in CDKN2A are aThe p70 p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single stranded DNA dependent ATP dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with