PERK Monoclonal Antibody, 100ul In vitro Assessment Represses the transcription of a

Represses the transcription of a number of genes including gastrin and ornithine decarboxylase

Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway

The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D

Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase

May be a transcriptional repressor

PERK Monoclonal Antibody, 100ul In vitro Assessment Represses the transcription of aThe protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in