FRP-2 Polyclonal Antibody, 50ul Microbial Genome Editing Defects in ATG16L1 are a

Defects in ATG16L1 are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10)

The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage

Unlike the other two isoforms| p46Shc is targeted to the mitochondrial matrix

Stimulates the autophosphorylation and kinase activity of STK38 and STK38L

it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins

FRP-2 Polyclonal Antibody, 50ul Microbial Genome Editing Defects in ATG16L1 are aSFRP2 encodes a member of the SFRP family that contains a cysteine rich domain homologous to the putative Wnt binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of SFRP2 is a potential marker for the presence of colorectal cancer.