HDAC1 (Acetyl Lys432) Rabbit Polyclonal Antibody, 20ul Petri Dishes Mutations in this gene are

Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation| type IIk

|subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP beta and gamma

Mutations have also been associated with non-insulin-dependent diabetes mellitus type II| an autosomal dominant disease of defective insulin secretion

A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components

An important paralog of SLC4A1AP is PPP1R8

HDAC1 (Acetyl Lys432) Rabbit Polyclonal Antibody, 20ul Petri Dishes Mutations in this gene areCatalytic activity: Hydrolysis of an N(6) acetyl lysine residue of a histone to yield a deacetylated histone. Responsible for the deacetylation of lysine residues on the N terminal part of the core histones (H2A H2B H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation cell cycle progression and developmental events. Histone deacetylases act via the formation of large