APBB3 Rabbit Polyclonal Antibody, 100ul Funnels The protein has serine/threonine kinase

The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac

where most individuals have one to five copies

Using array analysis

The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance

Alternatively spliced transcript variants encoding multiple isoforms have been observed for ITCH

APBB3 Rabbit Polyclonal Antibody, 100ul Funnels The protein has serine/threonine kinaseThe protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta amyloid precursor protein (APP) as well as to other APP like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene.