Sec16A Polyclonal Antibody, 20ul Glassware Sets CRKL encodes a protein kinase

CRKL encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion

and gene expression in developmental processes

In addition| this protein interacts with and phosphorylates BRCA1| allowing BRCA1 to restore survival after DNA damage

Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification

and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion

Sec16A Polyclonal Antibody, 20ul Glassware Sets CRKL encodes a protein kinaseThis gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms.