IGF-IR Polyclonal Antibody, 50ul[BT-AP04396] Culture Media This receptor belongs to the

This receptor belongs to the G-protein coupled receptor 1 family

In vitro assays indicate the protein lacks phosphorylation activity

Members of the subfamily share similarity in sequence and splice sites

This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein

This gene product is a secreted neurotrophic factor but lacks a typical signal peptide

IGF-IR Polyclonal Antibody, 50ul[BT-AP04396] Culture Media This receptor belongs to theInsulin like growth factor 1 receptor binds insulin like growth factor with a high affinity. It has tyrosine kinase activity. The insulin like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding