Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Catalase is a heme enzyme

Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells

The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55

Eight alternatively spliced transcript variants have been described

Mutations in this gene are associated with generalized glucocorticoid resistance

subcellular location:Expressed diffusely throughout the nucleus

Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Catalase is a heme enzymeThe protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.