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IDS Polyclonal Antibody, 20ul Custom DNA Oligos SIAH2 encodes E3 ubiquitin-protein ligase

SKU: 29130237286

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IDS Polyclonal Antibody, 20ul Custom DNA Oligos SIAH2 encodes E3 ubiquitin-protein ligaseThis gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X linked lysosomal storage disease mucopolysaccharidosis type II also known as Hunter syndrome. Alternative splicing results in multiple transcript variants at

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Description

SIAH2 encodes E3 ubiquitin-protein ligase SIAH2 that is a member of the seven in absentia homolog (SIAH) family

The genes encoding these microtubule constituents belong to the tubulin superfamily

The protein encoded by LGALS2 is a soluble beta-galactoside binding lectin

The heavy chain includes a globular motor domain| which catalyzes ATP hydrolysis and interacts with actin| and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil

binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium

IDS Polyclonal Antibody, 20ul Custom DNA Oligos SIAH2 encodes E3 ubiquitin-protein ligaseThis gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X linked lysosomal storage disease mucopolysaccharidosis type II also known as Hunter syndrome. Alternative splicing results in multiple transcript variants at

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