CD6 Polyclonal Antibody, 100ul[BT-AP01522] Human Genome Knockout Libraries Alpha chains of type IV

Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus| frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix)| and a short N-terminal triple-helical 7S domain

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum

thus| it functions as a regulator of a wide variety of downstream proteins| including tumor suppressor proteins p53 and BRCA1| checkpoint kinase CHK2| checkpoint proteins RAD17 and RAD9| and DNA repair protein NBS1

Several transcript variants encoding different isoforms of supervillin have been described

also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation

CD6 Polyclonal Antibody, 100ul[BT-AP01522] Human Genome Knockout Libraries Alpha chains of type IVCD6 (CD6 molecule) encodes a protein found on the outer membrane of T lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. CD6 product is important for continuation of T cell activation. CD6 may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants