RFWD3 Polyclonal Antibody, 100ul DNA Fragments regulatory peptides of the brain

regulatory peptides of the brain and gastrointestinal tract

GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane

In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts

Several pseudogenes of this gene are found on other chromosomes

Belongs to the DNA polymerase alpha subunit B family

RFWD3 Polyclonal Antibody, 100ul DNA Fragments regulatory peptides of the brainRFWD3, also named as RNF201, is a E3 ubiquitin protein ligase that mediates the ubiquitination of p53 TP53 in the late response to DNA damage, and acts as a positive regulator of p53 TP53 stability, thereby regulating the G1 S DNA damage checkpoint. RFWD3 may act by catalyzing the formation of short polyubiquitin chains on p53 TP53 that are not targeted to the proteasome. In response to ionizing radiation, It interacts with MDM2 and enhances p53 TP53