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This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator

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which are involved in a range of biological activities including cell growth

disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD)

PLCB1 Polyclonal Antibody, 20ul Vector Construction Trust in our quality forThe protein encoded by this gene catalyzes the formation of inositol 1,4,5 trisphosphate and diacylglycerol from phosphatidylinositol 4,5 bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G protein alpha subunits, alpha q and alpha 11. Two transcript variants encoding different isoforms have been found for this gene.